Sunday, December 16, 2012

I'm Going to Miss Those Hallucinations

Years ago, ketamine was found to have an "instant antidepressant" effect -- even in depressed people who had failed to improve when taking conventional antidepressants. Ketamine caused improved moods within hours -- instead of several weeks with typical antidepressants. And the effect of just one dosage of ketamine lasted up to several weeks. The main problem with ketamine, for most people, is the hallucinations.

Recent US clinical Phase IIA trials of the drug GLYX-13 -- a drug with similar neurological effects as ketamine -- show encouraging results for treating depression. Similar to ketamine in effect, but without the hallucinations.
The Phase IIa results show that a single administration of GLYX-13 produced statistically significant reductions in depression scores in subjects who had failed treatment with one or more antidepressant agents. The reductions were evident within 24 hours and persisted for an average of seven days. Importantly, the effect size, a measure of the magnitude of the drug's antidepressant efficacy, observed at 24 hours and at seven days after a single administration of GLYX-13, was nearly double the effect size seen with most other antidepressant drugs after 4-6 weeks of repeated dosing.

In the Phase IIa trial, GLYX-13 was well tolerated. Reported side effects were mild to moderate and were consistent with those observed in subjects receiving placebo. Consistent with previous studies, GLYX-13 did not produce any of the schizophrenia-like psychotomimetic effects associated with other drugs that modulate the NMDA receptor. _News Medical Net
[satire on]

Ever since Al Fin discovered the rapid antidepressant effects of ketamine, he has insisted that all Al Fin blog writers whose postings start to trend too dark, must come in to the office for an injection of ketamine from the blog physician's assistant.

At first, I was troubled by the visions and hallucinations. But then I learned to control my dream destinations, and the persons and creatures I met.

Sure, they had to strap me down to the table for an hour or two. But it was worth it. What was the alternative? Write for Huffington Post? They are crap to write for, and Ariana is the cheapest of cheapskates -- not to mention totally loony.

After each injection, I could go weeks and weeks without turning to the dark side of writing. In many ways, I think I am a better writer for it, too. Ketamine is a much better alternative than electroconvulsive therapy (ECT), from everything I have read.

The hallucinations? My favorite one became a recurring vision with each injection. It involved a princess who would meet me outside her castle, and . . . Well it's my hallucination and you can't have it.

Neither will I be able to, either, once GLYX-13 is approved and on the market. Mr. Fin knows about the drug, so I am not revealing any secrets. He has already sent a memo to those of us who receive the treatments, advising us of his plans to change over to the new treatment, once it is legally available. All I can do is enjoy the hallucinations while they last.[satire off]

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At CIIT MCA classes in Noida is conducted by subject experts corporate professionals with 9+ years of experience in managing real-time and live projects. Sofracle Nano Specialized MCA classes Noida is the perfect blend of academic learning and practical sessions to provide maximum exposure to students that transform an average student into a corporate professional whom companies prefer to hire.

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2:19 AM  
Blogger CIIT Noida said...

CIITN is located in Prime location in Noida having best connectivity via all modes of public transport. CIITN offer both

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3:02 AM  
Blogger CIIT Noida said...

Hadoop Training Institute in Noida, The Hadoop

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CONTAC CIITN:

B-12, Sector - 2, Noida, U.P
State - Uttar Pradesh U.P
Country - India
Pin Code - 201301

Phone - +917290926565
Mon - Sun: 10am - 6pm

2:07 AM  
Blogger CIIT Noida said...

CIITN provides Best java training in noida based on current industry standards that helps attendees to secure placements in their dream jobs at MNCs.The curriculum of our Java training institute in Noida is designed in a way to make sure that our students are not just able to understand the important concepts of the programming language but are also able to apply the knowledge in a practical way.

if you are looking for the best oracle sql certification center in Noida, CIIT is worth to consider. CIIT is a oracle training institute offering best sql course, oracle training, sql certification and oracle dba training at affordable price. Best Oracle training in Noida.

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12:15 AM  
Blogger Manoj said...

Beproject centre provides mca mini projects in chennai and give summer course for java, dotnet,matlab, embedded, iot, php&mysql courses are available. matlab projects in chennai courses for ECE/EEE students.

5:20 AM  
Blogger CIIT Noida said...

CIITN provides Best java training in noida based on current industry standards that helps attendees to secure placements in their dream jobs at MNCs.The curriculum of our Java training institute in Noida is designed in a way to make sure that our students are not just able to understand the important concepts of the programming language but are also able to apply the knowledge in a practical way.

if you are looking for the best oracle sql certification center in Noida, CIIT is worth to consider. CIIT is a oracle training institute offering best sql course, oracle training, sql certification and oracle dba training at affordable price. Best Oracle training in Noida.

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1:53 AM  
Blogger ciit noida said...

HADOOP TRAINING INSTITUTE IN NOIDA

CIITN provides Big data hadoop training in Noida in Noida as per the current industry standards. Our training programs will enable professionals to secure placements in MNCs. CIITN is one of the most recommended Hadoop Training Institute in Noida that offers hands on practical knowledge/practical implementation on live projects and will ensure the job with the help of advance level Hadoop Training Courses. At CIITN Hadoop Training in Noida is conducted by specialist working certified corporate professionals having 8+ years of experience in implementing real-time Hadoop projects.CIITN is the best Hadoop training center in Noida with a very high level infrastructure and laboratory facility. The most attractive thing is that candidates can opt multiple IT training course at Noida location. We feel proud by announce that CIITN prepares thousands of candidates for Hadoop training at sensible fees structure which is sufficient for best Hadoop training in Noida to attend the Hadoop classes.Hadoop training course includes “Knowledge by Experiments” strategy to get Hadoop training and performing real-time practices and real-time modulation. This extra ordinary practices with live environment experience in Hadoop Training certifies that you are ready to apply your Hadoop knowledge in big corporations after the Hadoop training in Noida completed.


Big data hadoop training in Noida

B-12, Sector - 2, Noida, U.P
State - Uttar Pradesh U.P
Country - India
Pin Code - 201301

Phone - +917290926565
Mon - Sun: 10am - 6pm

10:44 PM  
Blogger Dida ELhaik said...


تعد شركة تركيب اثاث ايكيا بالرياض هي الشركة الرائده والاولي في كافة الاثاث من تركيب وفك ونقل وتخزين وكافة الاعمال المتعلقة بالاثاث في الرياض وكافة المناطق والمحافظات بالمملكة العربية السعودية، وقد تصدرت شركة خبراء المملكة لتكون الأولى في مجال فك ونقل وتركيب الأثاث المنزلي وايضا فك وتركيب الستائر بالرياض وهي تتميز عن باقي شركات الرياض نظرا لما تقدمة من خدمات بشكل احترافي كما انها تتميز عن غيرها بكفاءة الفنيين والامتخصصين في مجال تركيب الاثاث فلا داعي لكثرة البحث فلديك خبراء المملكة فهم فعلا خبراء ومتميزون في جميع خدماتهم المقدمة
شركة تركيب اثاث ايكيا بالرياض
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شركة تركيب عفش بالرياض
ما يميز شركة تركيب نقل وتركيب اثاث بالرياض
- تعد شركة تركيب اثاث ايكيا من الشركات المفضلة لكثير من العملاء فهم من منحوها الصدارة والتميز لتميز الخدمات المقدمة لهم وهي الاولي في تركيب الاثاث لزيادة خبراتها الكبيرة لسنوات.
تتميز ايضا شركة خبراء المملكة بكبر فرق العمل المتخصصة والمدربة بمهاره وتقنية عالية كما اننا ندعم صفوفنا بصفة مستمرة من العمال والموظفين والفنيين الأكفاء والمهرة كما انها Jستقبل العمالة الفليبنية

12:04 PM  
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1:18 AM  
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3:44 AM  
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12:22 AM  

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